Hidradenitis suppurativa and atopic dermatitis: A 2-way association - 13/02/21

Doi : 10.1016/j.jaad.2020.12.051

Shany Sherman, MD ^a,^b,^⁎ , Khalaf Kridin, MD, PhD ^c, Dana Tzur Bitan, PhD ^b,^d,^e, Yael Anne Leshem, MD, MCR ^a,^b, Emmilia Hodak, MD ^a,^b, Arnon Dov Cohen, MD, PhD ^f,^g
^a Division of Dermatology, Rabin Medical Center–Beilinson Hospital, Petach Tikva, Israel
^b Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
^c Lubeck Institute of Experimental Dermatology, Lubeck, Germany
^d Department of Behavioral Sciences, Ariel University, Ariel, Israel
^e Shalvata Mental Health Center, Hod Hasharon, Israel
^f Department of Quality Measurements and Research, Chief Physician Office, Clalit Health Services, Tel Aviv, Israel
^g Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel

^∗Correspondence to: Shany Sherman, MD, Division of Dermatology, Rabin Medical Center–Beilinson Hospital, Petach Tikva, Israel 4941492.Division of DermatologyRabin Medical Center–Beilinson HospitalPetach Tikva4941492Israel

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Saturday 13 February 2021
Cet article a été publié dans un numéro de la revue, cliquez ici pour y accéder

Abstract

Background

The coexistence of hidradenitis suppurativa (HS) and atopic dermatitis (AD) had been reported but, to our knowledge, was not investigated in controlled studies.

Objective

To evaluate the bidirectional association between HS and AD.

Methods

A population-based retrospective cohort study was conducted to compare the incidence rate of AD among patients with HS (n = 6779) and age-, sex-, and ethnicity-matched control individuals (n = 33,260). Adjusted hazard ratios (HRs) and adjusted odds ratios were estimated.

Results

The incidence of AD was 2.51 (95% confidence interval [CI], 2.07-3.02) and 1.24 (95% CI, 1.10-1.40) per 1000 person-years among patients with HS and control individuals, respectively. Patients with HS were twice as likely to develop AD as control individuals (HR, 2.06; 95% CI, 1.64-2.58). Furthermore, the prevalence of pre-existing AD was higher in patients with HS than in control individuals (2.5% vs 1.8%, respectively; P < .001). A history of AD was associated with a 40% increase in the odds of HS (odds ratio, 1.41; 95% CI, 1.19-1.67). Relative to patients with isolated HS, those with a dual diagnosis of HS and AD were younger and had a female predominance, lower prevalence of smoking, and lower body mass index.

Limitations

Retrospective data collection.

Conclusions

A bidirectional association between HS and AD was observed. Dermatologists should be aware of this association.

Le texte complet de cet article est disponible en PDF.

Key words : atopic dermatitis (AD), bidirectional association, case-control study, cohort study, hidradenitis suppurativa (HS)

Abbreviations used : AD, CHS, CI, HR, HS, IL, OR, SD, Th

Plan

Methods

Study design and data set

Study population and definition of main variables and covariates

Statistical analysis

Results

Characteristics of the study population

The risk of developing AD among patients with HS

The odds of developing HS with a pre-existing diagnosis of AD

The epidemiologic and clinical features of patients with HS and AD relative to the remaining patients with HS

Discussion

	Drs Sherman and Kridin contributed equally to this article.
	Funding sources: None.
	IRB approval status: Reviewed and approved by the local institutional Helsinki review board (approval no. 0212-17-COM).
	Reprints not available from the authors.