Expression of nerve growth factor (NGF) in endometrium as a potential biomarker for endometriosis – Single tertiary care centre study - 14/02/21

Doi : 10.1016/j.jogoh.2020.101895

Maria Szubert ^a,^b,^⁎ , Magdalena Rogut ^c, Magdalena Ziętara ^a,^b, Tomasz Wierzbowski ^a,^b, Jacek Wilczyński ^a,^b, Małgorzata Czyż ^c
^a Department of Surgical and Oncological Gynecology, 1stDepartment of Gynecology and Obstetrics, Medical University of Lodz, Poland
^b M. Pirogow’s Teaching Hospital, Wileńska 37 Street, 94-029, Lodz, Poland
^c Department of Molecular Biology of Cancer of Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland

^⁎Corresponding author at: M. Pirogow’s Teaching Hospital, Wilenska 37, 94-029, Lodz, Poland.M. Pirogow’s Teaching HospitalWilenska 37Lodz94-029Poland

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Abstract

Objective

to identify novel biomarkers for peritoneal endometriosis in eutopic endometrium thus giving an oportunity for non-invasive diagnosis.

Design

A cross-sectional single-center study

Setting

tertiary care hospital

Patients

49 patients subjected to laparoscopy because of suspected endometriosis, 33 patients out of the group qualified to the study had sufficient endometrial tissue taken and were in their follicular phase of menstrual cycle.

Interventions

biopsy sampling of eutopic endometrial tissue during diagnostic or diagnostic and terapeutic laparoscopy, questionaires,

Main Outcome Measure(s)

qRT-PCR to evaluate the mRNA expression of selected candidate marker genes in endometrium: ARO1 (aromatase), CXCL8 (interleukin 8), NGF (nerve growth factor), VEGF-A (vascular endothelial growth factor A), PDGF-A (platelet-derived growth factor A).

Results

mRNA expression of ARO1, CXCL8, VEGF-A and PDGF-A did not differ significantly between women with and without endometriosis. NGF mRNA expression was decreased in women with endometriosis.

Conclusions

Observed preliminary results suggest a possible role of NGF in early diagnosis of peritoneal endometriosis. The role of NGF changes in eutopic endometrium of patients with peritoneal endometriosis needs further evaluation.

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Abbreviations : ARO1, CXCL8, CRP, NGF, VEGF-A, PDGF-A, ASRM

Keywords : NGF, PDGF, ARO, Eutopic endometrium, Endometriosis