Serum transforming growth factor β and leucine-rich α-2-glycoprotein 1 as potential biomarkers for diagnosis of uterine leiomyomas - 14/02/21
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Abstract |
Background and aim |
Transforming growth factor β (TGF-β) and leucine-rich α-2-glycoprotein 1 (LRG1) play significant roles in the pathogenicity of uterine leiomyomas (ULMs). The current study aimed to assess the diagnostic values of serum TGF-β and LRG1 in terms of the presence and severity of ULMs.
Methods |
Premenopausal women with ULMs (n=44) together with age-adjusted ULM-free individuals (n=41) were incorporated into the study. ULMs were detected and evaluated using transvaginal ultrasonography. Serum levels of TGF-β and LRG1 were quantified by enzyme-linked immunosorbent assay.
Results |
Mean concentrations of serum TGF-β and LRG1 were significantly higher in the group of patients with ULMs compared to the control group (p<0.05). The volume of the largest leiomyoma was positively correlated with the levels of TGF-β (r = 0.414, p= 0.005) and LRG1 (r = 0.341, p= 0.023). The receiver-operating characteristics analysis demonstrated moderate and robust values of area under the curve for TGF-β (0.755) and LRG1 (0.90), respectively.
Conclusion |
Increases in serum levels of TGF-β and LRG1 is associated with the incidence and severity of ULMs. LRG1 in particular but also TGF-β may be able to serve as reliable biomarkers for the diagnosis and monitoring of ULMs.
Le texte complet de cet article est disponible en PDF.Abbreviations : ANOVA, AUC, BMI, CA125, CV, ECM, HLA-G, LDH, LRG1, MMPs, MRI, ROC, SD, TGF-β, ULMs, VEGF
Keywords : Leiomyoma, Fibrosis, Biomarkers, Transforming growth factor beta, Leucine-Rich alpha-2-glycoprotein 1
Plan
Vol 50 - N° 3
Article 102037- mars 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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