Five-year survival in patients with nodular and superficial spreading melanomas in the US population - 17/02/21
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Abstract |
Background |
Although superficial spreading melanomas (SSM) are diagnosed as thinner lesions, nodular melanomas (NM) have a more rapid growth rate and are biologically more aggressive compared with other histologic subtypes.
Objective |
To determine the difference in 5-year relative survival in patients with NM and SSM at the same Breslow depth and TNM stage.
Methods |
A population-based cross-sectional analysis compared the 5-year relative survival of patients with NM and SSM using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER)∗Stat software (version 8.2.1-8.3.5). Chi-square tests compared the proportions, and Kaplan-Meier method with Z-score compared 5-year relative survival.
Results |
For patients receiving a diagnosis between 2004 and 2009, 5-year relative survival was lower in NM compared with SSM (53.7% vs 87.3%; Z score, –41.35; P < .001). Similarly, for patients receiving a diagnosis between 2010 and 2015, 5-year relative survival was lower in NM compared with SSM (61.5% vs 89.7%; Z score, –2.7078; P < .01). Subgroup analyses showed inferior survival in NM in T1b, and survival differences remained significant after excluding patients with nodal or distant metastases.
Conclusions |
Five-year relative survival is worse in NM compared with SSM especially in T1b, T2a, and T2b melanomas. Melanoma subtype should be taken into consideration when making treatment recommendations.
Le texte complet de cet article est disponible en PDF.Key words : 5-year survival, nodular melanoma, overall survival, superficial spreading melanoma
Abbreviations used : AJCC, CI, HR, NM, SEER, SLN, SLNB, SSM
Plan
Funding sources: None. |
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IRB status: Not applicable. |
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Reprints not available from the authors. |
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