Effect of cultivation ages on anti-inflammatory activity of a new type of red ginseng - 19/02/21
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Graphical abstract |
Highlights |
• | Analysis the original different compounds of fresh ginseng of four to seven years. |
• | UPLC-QTOF-MS/MS combine with multivariate statistical method to identify the potential marker ions. |
• | 6-year-old NRG has high level of rare ginsenosides and strong anti-inflammatory activity than that by 4-year-old NRG. |
• | Illustrate the components transformation of NRG and the six years old ginseng was more suitable for clinical application. |
Abstract |
Ginseng has been widely applied in clinical practice, but the cultivation age cannot be ignored as it influences the quality of ginseng and its products. In this work, different cultivation ages of fresh ginseng (FG) from four to seven years were analysed by UPLC-Q-TOF-MS/MS. Principal component analysis and supervised orthogonal partial least squared discrimination analysis, which belong to the normal method of multivariate statistical analysis, were applied to discover the characteristic components of FG at different cultivation ages. The components of new type of red ginseng (NRG) derived from FG at different cultivation ages were compared by HPLC analysis. The pharmacological anti-inflammatory activity was evaluated by ELISA and qPCR. The result showed that the characteristic components of both 6- and 7-year-old ginseng were ginsenoside Rb1, mal-ginsenoside Rb1, ginsenoside Rc, mal-ginsenoside Rc, mal-ginsenoside Rb1 isomer, and mal-ginsenoside Rb2. Moreover, the characteristic components of both 4- and 5-year-old ginseng were ADP-glucose and 3-hydroxyhexanoyl CoA. In addition, 6-year-old NRG has higher rare ginsenosides than 4-year-old NRG, which possesses great anti-inflammatory activity in vitro. The results reveal the ginsenoside transformation law of NRG processing and suggest that the cultivation age of FG influences the content of ginsenosides in NRG. Therefore, 6-year-old ginseng is more suitable for red ginseng processing and clinical use.
Le texte complet de cet article est disponible en PDF.Keywords : Cultivation ages, UPLC-Q-TOF-MS/MS, MVA, Red ginseng, Anti-inflammatory
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Vol 136
Article 111280- avril 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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