HLA Class II alleles and association with HPV Infection prevalence in high-risk HPV-positive Han women in southern China - 20/02/21
, Boan Li a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | We first determined the distribution of high-risk HPV subtypes in women from Maoming City and revealed several susceptibility alleles and a possible protective factor for HPV infection. |
• | Unlike the European population, −DQB1*0402 may protect rather than render Maoming women susceptible to HPV infection. |
Abstract |
Objective |
To investigate the prevalence of different human papillomavirus (HPV) subtypes and their association with human leukocyte antigen (HLA) class II alleles in China.
Patients and methods |
A total of 16,168 married Chinese women in Maoming City of Guangdong province were tested for high-risk HPV infection. High-resolution typing of HLA-DRB1/DQB1 alleles was also performed on samples found to be infected with HPV.
Results |
All in all, HPV-52, −58, −16, −18, and −53 were the five most common subtypes of HPV, with an incidence of high-risk HPV infection of 7.14%. Among women at high-risk of HPV infection, −DRB1*0403 (3.12% vs. 1.67%, odds ratio [OR] 1.894), −DQB1*0602 (3.74% vs. 1.82%, OR 2.094), and −DQB1*0609 (2.02% vs. 0.91%, OR 2.249) frequencies were higher than in controls. In contrast, −DQB1*0402 (0.31% vs. 1.29%, OR 0.239) in women with high-risk HPV infection exhibited a significantly decreased frequency compared to the controls.
Conclusion |
Our results strongly support previous findings from other populations that −DRB1*0403 and −DQB1*0602 may be risk factors for HPV infection and subsequent development of cervical cancer. Moreover, unlike the European population, −DQB1*0402 may protect rather than render Maoming women susceptible to HPV infection.
Le texte complet de cet article est disponible en PDF.Keywords : Human papillomavirus, Infection, Human leukocyte antigen, Cervical cancer, Allele
Plan
Vol 51 - N° 1
P. 67-70 - février 2021 Retour au numéro
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