Major cerebral vessels involvement in patients with MELAS syndrome: Worth a scan? A systematic review - 25/02/21
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Abstract |
Major cerebral vessels have been proposed as a target of defective mitochondrial metabolism in patients with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes syndrome (MELAS). Cerebral angiographic techniques are not routinely performed in MELAS patients. A systematic literature review was performed to identify studies describing major vessel caliber alterations in MELAS. Twenty-three studies reporting on 46 MELAS patients were included. Alterations in major caliber vessels were present in 59% (27/46) of patients. Dilation occurred in 37% (17/46) of patients, and in 88% (15/17) of them during a stroke-like episode (SLE). Stenosis was reported in 24% (11/46) of patients: 36% (4/11) related to an SLE and 64% (7/11) to dissections or degenerative changes.
During an SLE, identification of intracranial vessels dilation or stenosis could be a selection tool for new treatment protocols. Outside SLE, identification of major cerebral vessels dissections and degenerative changes may help to prevent subsequent complications.
Le texte complet de cet article est disponible en PDF.Abbreviations : CTA, COX, DWI, DSA, ICA, MCA, MELAS, MRA, MRI, MCAD, NO, PICO, PCA, SLE, SLL, TOF
Keywords : MELAS, Magnetic resonance angiography, Magnetic resonance imaging
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