The effects of immunostimulatory herbal supplements on autoimmune skin diseases - 10/03/21
Abstract |
The use of herbal supplements that promise to improve immune health has gained popularity among dermatology patients. However, there is little to no evidence that herbal supplements improve dermatologic conditions. Several in vitro and in vivo studies have shown that Spirulina platensis, Aphanizomenon flos-aqua, Chlorella, Echinacea, and alfalfa activate immune cells via certain cytokines and chemokines. Case reports suggest the association of ingesting immunostimulatory herbs and the clinical onset or flares of diseases characterized by an exaggerated immune response such as lupus erythematosus, dermatomyositis, and autoimmune blistering disorders. Therefore, it is imperative to investigate the prevalence of herbal supplement use in this patient population. In addition, in vitro studies should examine the underlying mechanisms by which herbs stimulate immune pathways that are already overactive in autoimmune patients.
Le texte complet de cet article est disponible en PDF.Key words : alfalfa, Aphanizomenon flos-aqua, autoimmune skin diseases, Chlorella, complementary and alternative medicine, dermatomyositis, Echinacea, herbal supplement, lupus erythematosus, pemphigoid, pemphigus, Spirulina
Abbreviations used : CAM, IFN-α, IFN-β, NF-κB, IL, TNF-α, NK, LPS, Th1, Th2, mRNA
Plan
| Authors Bax, Chakka, and Concha are co-first authors. |
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| Funding sources: National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases grants K24-AR-02207 and R01-AR-071653, and National Center for Advancing Translational Sciences grant TL1-TR-001880 to C.E.B. This work was supported by the United States Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development and Biomedical Laboratory Research and Development. |
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| Conflicts of interest: None disclosed. |
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| IRB approval status: Not applicable. |
Vol 84 - N° 4
P. 1051-1058 - avril 2021 Retour au numéro
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