Eruptions and related clinical course among 296 hospitalized adults with confirmed COVID-19 - 10/03/21
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Abstract |
Background |
Limited information exists on mucocutaneous disease and its relation to course of COVID-19.
Objective |
To estimate prevalence of mucocutaneous findings, characterize morphologic patterns, and describe relationship to course in hospitalized adults with COVID-19.
Methods |
Prospective cohort study at 2 tertiary hospitals (Northwell Health) between May 11, 2020 and June 15, 2020.
Results |
Among 296 hospitalized adults with COVID-19, 35 (11.8%) had at least 1 disease-related eruption. Patterns included ulcer (13/35, 37.1%), purpura (9/35, 25.7%), necrosis (5/35, 14.3%), nonspecific erythema (4/35, 11.4%), morbilliform eruption (4/35, 11.4%), pernio-like lesions (4/35, 11.4%), and vesicles (1/35, 2.9%). Patterns also showed anatomic site specificity. A greater proportion of patients with mucocutaneous findings used mechanical ventilation (61% vs 30%), used vasopressors (77% vs 33%), initiated dialysis (31% vs 9%), had thrombosis (17% vs 11%), and had in-hospital mortality (34% vs 12%) compared with those without mucocutaneous findings. Patients with mucocutaneous disease were more likely to use mechanical ventilation (adjusted prevalence ratio, 1.98; 95% confidence interval, 1.37-2.86); P < .001). Differences for other outcomes were attenuated after covariate adjustment and did not reach statistical significance.
Limitations |
Skin biopsies were not performed.
Conclusions |
Distinct mucocutaneous patterns were identified in hospitalized adults with COVID-19. Mucocutaneous disease may be linked to more severe clinical course.
Le texte complet de cet article est disponible en PDF.Key words : adults, COVID-19, eruption, hospitalized, morbilliform, mucocutaneous, necrosis, Northwell, purpura, rash, SarsCoV-2, ulcer
Abbreviations used : AKI, BMI, CI, IQR
Plan
| Funding Sources: None. |
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| IRB approval status: This investigation was approved by the Human Subjects Committee at the Feinstein Institute for Medical Research at the Northwell Health. |
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| Reprints not available from the authors. |
Vol 84 - N° 4
P. 946-952 - avril 2021 Retour au numéro
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