The effect of widespread HBV vaccination on the prevalence of HDV remains largely unknown.
This study estimated a prevention of 12 million HDV cases by HBV vaccination in the general population.
HDV prevalence is increased in HBV carriers.
The global burden of HDV remains substantial requiring enhanced awareness and intervention.
Abbreviations : HDV, HBV, HBsAg, WHO, HCV, HIV, HCC, HepB3, PRISMA, IDUs, CI