CT and MRI characteristics of ovarian mature teratoma in patients with anti-N-methyl-D-aspartate receptor encephalitis - 28/03/21
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Graphical abstract |
Highlights |
• | Teratomas in patients with anti-N-methyl-d-aspartate receptor encephalitis (NMDAR-E) are smaller than those in patients without NMDAR-E. |
• | Teratomas in patients with NMDAR-E have fewer teeth/calcification than those in patients without NMDAR-E. |
• | Teratomas in patients with NMDAR-E have smaller fat component than those in patients without NMDAR-E. |
Abstract |
Purpose |
The purpose of this study was to determine the computed tomography (CT) and magnetic resonance imaging (MRI) characteristics of ovarian mature teratoma in patients with anti-N-methyl-d-aspartate receptor encephalitis (NMDAR-E).
Materials and Methods |
A total of 125 women (mean age, 40.9±17.8 [SD] years; age range: 12–85 years) with 146 histopathologically or radiologically proven ovarian mature teratomas who underwent preoperative CT and MRI examinations were retrospectively included. Eight patients with 11 teratomas had NMDAR-E, whereas 117 patients with 135 teratomas did not have NMDAR-E. CT and MRI examinations were retrospectively reviewed and teratomas in patients with NMDAR-E were compared to those in patients without NMDAR-E. Comparisons were performed using Mann-Whitney U test or Fisher exact test.
Results |
In patients with NMDAR-E, maximum diameter of teratomas (26.1±9.3 [SD] mm), prevalence of teeth/calcification (36%) and rate of occupation by fat components (26%) were lower than those in patients without NMDAR-E (67.0±37.6 [SD] mm [P<0.01]; 75% [P<0.05]; and 65%[P<0.01], respectively). More than 75% of space was occupied by fat components in 76/135 teratomas (56%) in patients without NMDAR-E, whereas this was not observed in any teratoma in patients without NMDAR-E.
Conclusion |
By comparison with teratomas in patients without NMDAR-E, teratomas in patients with NMDAR-E are smaller, have few teeth/calcification, and the amount of space occupied by fat components is smaller.
Le texte complet de cet article est disponible en PDF.Keywords : Teratoma, Ovarian, Anti-N-methyl-D-aspartate receptor encephalitis, Tomography, X-ray computed, Magnetic resonance imaging (MRI)
Abbreviations : CT, HU, NMDAR-E, MRI, SD
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