Automated brain MRI metrics in the EPIRMEX cohort of preterm newborns: Correlation with the neurodevelopmental outcome at 2 years - 31/03/21
, Pierre Bertault b, Géraldine Favrais c, Elsa Tavernier d, Barthelemy Tosello e, f, Nathalie Bednarek g, Laurent Barantin b, Alexandra Chadie h, Maia Proisy i, Yongchao Xu j, Isabelle Bloch k, Dominique Sirinelli a, b, Catherine Adamsbaum l, m, Clovis Tauber b, Elie Saliba b, cEPIRMEX study groupa, b, c, d, e, f, g, h, i, j, k, l, m
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Highlights |
• | Brain metrics are available on two-dimensional premature brain MRI in daily practice. |
• | There is a correlation between surfaces of the main brain structures on MRI and neurodevelopment. |
• | Diffuse excessive high signal intensity of the white matter does not correlate with neurodevelopment evaluation at 2 years of age. |
Abstract |
Purpose |
The purpose of this study was to identify in the EPIRMEX cohort the correlations between MRI brain metrics, including diffuse excessive high signal intensities (DEHSI) obtained with an automated quantitative method and neurodevelopmental outcomes at 2 years.
Materials and methods |
A total of 390 very preterm infants (gestational age at birth≤32 weeks) who underwent brain MRI at term equivalent age at 1.5T (n=338) or 3T (n=52) were prospectively included. Using a validated algorithm, automated metrics of the main brain surfaces (cortical and deep gray matter, white matter, cerebrospinal fluid) and DEHSI with three thresholds were obtained. Linear adjust regressions were performed to assess the correlation between brain metrics with the ages and stages questionnaire (ASQ) score at 2 years.
Results |
Basal ganglia and thalami, cortex and white matter surfaces positively and significantly correlated with the global ASQ score. For all ASQ sub-domains, basal ganglia and thalami surfaces significantly correlated with the scores. DEHSI was present in 289 premature newborns (74%) without any correlation with the ASQ score. Metrics of DEHSI were greater at 3T than at 1.5T.
Conclusion |
Brain MRI metrics obtained in our multicentric cohort correlate with the neurodevelopmental outcome at 2 years of age. The quantitative detection of DEHSI is not predictive of adverse outcomes. Our automated algorithm might easily provide useful predictive information in daily practice.
Le texte complet de cet article est disponible en PDF.Keywords : White matter, Premature, Magnetic resonance imaging, Brain, Cohort studies
Abbreviations : ASQ, BGT, DEHSI, GA, MRI, SD, TEA, WA
Plan
Vol 102 - N° 4
P. 225-232 - avril 2021 Retour au numéro
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