Expression of matrix metalloproteinases and their inhibitors at the implantation site in ampullary ectopic pregnancies - 15/04/21
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Abstract |
Objective |
This study investigated the qualitative and semi-quantitative expression of metalloproteinases (MMP) and their tissue inhibitors (TIMP) in trophoblastic tissue during ampullary ectopic pregnancies and correlated that expression with the degree of tubal invasion.
Study design |
It is a prospective study that included 34 patients diagnosed with ampullary tubal pregnancy who underwent salpingectomy. A histological evaluation of the depth of trophoblastic invasion in the tubes obtained was performed. Subsequently, the expression of the MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 and TIMP-3 markers was qualitatively and semi-quantitatively evaluated by indirect immunohistochemistry. In addition, the degree of trophoblastic invasion was correlated with the expression of each marker and with the metalloproteinase/inhibitor ratios.
Results |
MMP-2 (11.2 %; 3.6–17.9) was the marker with greater expression at the implantation site, both in the qualitative and semi-quantitative assessment, while MMP-9 (2.23 %; 0.2–5.4) and TIMP-3 (2.53 %; 0.1–15.3) were only weakly expressed.
Conclusion |
There was wide variation in expression among the markers and metalloproteinase/inhibitor ratios studied compared to the degrees of invasion.
Le texte complet de cet article est disponible en PDF.Keywords : Pregnancy, Ectopic, Metalloproteases, Matrix metalloproteases, Tissue inhibitor of metalloproteases, Matrix metalloprotease inhibitor
Plan
Vol 50 - N° 5
Article 102096- mai 2021 Retour au numéro
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