Protective effects of total flavonoids from Qu Zhi Qiao (fruit of Citrus paradisi cv. Changshanhuyou) on OVA-induced allergic airway inflammation and remodeling through MAPKs and Smad2/3 signaling pathway - 16/04/21
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Abstract |
Allergic asthma is one of the inflammatory diseases, which has become a major public health problem. Qu zhi qiao (QZQ), a dry and immature fruit of Citrus paradisi cv. Changshanhuyou, has various flavonoids with pharmacological properties. However, there is a knowledge gap on the pharmacological properties of QZQ on allergic asthma. Therefore, here, we explored the efficacy and mechanism of total flavonoids from QZQ (TFCH) on allergic asthma. We extracted and purified TFCH and conducted animal experiments using an Ovalbumin (OVA)-induced mice model. Bronchoalveolar lavage fluid and Swiss-Giemsa staining were used to count different inflammatory cells in allergic asthma mice. We conducted histopathology and immunohistochemistry to evaluate the changes in the lungs of allergic asthma mice. Moreover, we used ELISA assays to analyze chemokines and inflammatory cytokines. Furthermore, western blot analyses were conducted to elucidate the mechanism of TFCH on allergic asthma. We established that TFCH has anti-inflammatory effects and inhibits airway remodeling, providing a potential therapeutic strategy for allergic asthma.
Le texte complet de cet article est disponible en PDF.Abbreviations : AHR, AB-PAS, BALF, DEX, H&E, IFN-γ, MMPs, MAPKs, OVA, p-Smad2, p-Smad3, p-p38, p-Erk1/2, QZQ, TFCH, Th2
Keywords : Total flavonoids from QZQ, Allergic asthma, Anti-inflammatory, Airway remodeling, MAPKs and Smad2/3 signaling pathway
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Vol 138
Article 111421- juin 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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