The role of gut microbiota in tumorigenesis and treatment - 16/04/21
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Abstract |
A large number of microbial communities exist in normal human intestinal tracts, which maintain a relatively stable dynamic balance under certain conditions. Gut microbiota are closely connected with human health and the occurrence of tumors. The colonization of certain intestinal bacteria on specific sites, gut microbiota disturbance and intestinal immune disorders can induce the occurrence of tumors. Meanwhile, gut microbiota can also play a role in tumor therapy by participating in immune regulation, influencing the efficacy of anti-tumor drugs, targeted therapy of engineered probiotics and fecal microbiota transplantation. This article reviews the role of gut microbiota in the occurrence, development, diagnosis and treatment of tumors. A better understanding of how gut microbiota affect tumors will help us find more therapies to treat the disease.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Gut microbiota are directly or indirectly related to the occurrence of tumors, and there is a feedback effect between them. |
• | Interfering with the composition of gut microbiota can be a new way to explore the treatment of tumors. |
• | Gut microbiota is involved in host immune regulation and tumor immunotherapy. |
• | Intervention of gut microbiota can prevent the occurrence of tumors and contribute to the treatment. |
Keywords : Gut microbiota, Cancer, Immune system, Immunotherapy, Biomarkers, Fecal microbiota transplantation
Plan
Vol 138
Article 111444- juin 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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