Research progress on the pharmacological effect and clinical application of Tongqiao Huoxue Decoction in the treatment of ischaemic stroke - 16/04/21
, Yuan Wang a, b, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Ischaemic stroke (IS) is a common type of stroke characterised by sudden fainting and communication disorders, alongside a number of other symptoms. It is characterised by high morbidity, disability, and mortality rates. Tongqiao Huoxue Decoction (THD) is effective in the treatment of stroke. As a representative prescription for promoting blood circulation and removing blood stasis, THD has been widely used clinically. This paper systematically introduces clinical and experimental studies of THD in the treatment of IS, summarising its clinical application, pharmacological mechanisms, and active components in the treatment of IS. It also explores its key pathways in the treatment of IS through network pharmacology analyses, thereby speculating on its underlying mechanisms. It is of great significance for the secondary development of this classic prescription as well as for the research and development of new drugs.
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Highlights |
• | Ischaemic stroke symptoms similar to the manifestations of "stroke" in the TCM classics. |
• | Chemical constituents of six main traditional Chinese medicines in Tongqiao Huoxue Decoction (THD). |
• | THD exerts therapeutic efficacy on the ischemic stroke symptoms. |
• | Pharmacological mechanism and effective substance of THD for treating ischemic stroke. |
Abbreviations : THD, IS, MOS, FC, CD, RPR, RC, SP, HJ, FO, RZR, NR1, NF-κB, EAAC1, MCAO, TCMID, IL-1β, IL-6, TNF-α, EAA, AA, COX, PGI2, TXA2, Nrf, HO-1, SOD, Bcl-2, Bax, IL-10, hs-CRP, VEGF, NIHSS, TIA, LP-PLA2, LDL-C, LC3, mTOR, PI3K, Akt, SDF-1, CXCR4, MTL, GAS, Asp, MDA, KEGG, TLR, TCM
Keywords : Tongqiao Huoxue Decoction, Ischaemic stroke, Pharmacological mechanism, Clinical role
Plan
Vol 138
Article 111460- juin 2021 Retour au numéro
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