Preparation of double-layer nanoemulsions with controlled release of glucose as prevention of hypoglycemia in diabetic patients - 16/04/21
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Abstract |
Encapsulation systems promote targeted delivery to the gastrointestinal tract. An oil-in-water (O/W) nanoemulsion was covered using new delivery system composition based on zein and sodium alginate. The impact of aqueous phase (distilled water and cooked pumpkin puree), pH (2–4), and zein-alginate concentration solution (0.05–0.20% w/v) was investigated on particle size, zeta potential, incorporation efficiency (IE), stability, viscosity, and glucose release from single-layer (SLN) and double-layer nanoemulsion (DLN). DLNs showed a larger droplet size and zeta potential. The slow gradual release of glucose proved effective application of zein/alginate as delivery system for nanoemulsion. Moreover, cooked pumpkin and 0.12% of zein exhibited more delayed release of glucose than distilled water as an aqueous phase of DLN and as a delivery system respectively. Up-to-49% IE, up-to-50% stability in a period of 7-day storage, and controlled-release glucose for 240 min under in vitro gastrointestinal conditions were obtained in DLN. The results of the current study revealed that SLN covered by zein at 0.12% of concentration can be an ideal delivery system composition for patients with hypoglycemia and clinical problems.
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Highlights |
• | Double-layer nanoemulsions (DLN) were prepared according to emulsification method. |
• | Zein/alginate complex delivery system can control glucose release in simulated GIT. |
• | DLNs contain cooked puree of pumpkin exhibit better controlled release of glucose. |
• | DLN contains protein, plant oils, pectin and sucrose for hypoglycemia patients. |
• | Cooked pumpkin increased apparent viscosity of DLNs but decreased their stability. |
Keywords : Nanoemulsion, Encapsulation, Response surface methodology, Functional food, Controlled release
Plan
Vol 138
Article 111464- juin 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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