CISD2 plays a role in age-related diseases and cancer - 16/04/21
, Bei Liao b, c, 1 , Hai-Hong Zhang a, b, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
CDGSH iron-sulfur domain 2 (Cisd2) is an evolutionarily conserved protein that plays an important regulatory role in aging-related diseases and cancers. Since its discovery, Cisd2 has been identified as a regulatory factor for the aging of the human body and the regulation of mammalian lifespan. Cisd2 is also an oncoprotein that regulates the occurrence and development of cancer. Cisd2 mediates the occurrence of diseases related to human aging and the proliferation, differentiation, metastasis, and invasion of various cancer cells through various mechanisms. Multiple studies have shown that Cisd2 expression is related to the clinical characteristics of aging-related diseases and patients with cancer, and its expression profile is a novel diagnostic and prognostic biomarker for a variety of human diseases. Modulating the expression or function of Cisd2 may be a potential treatment strategy for different diseases. In this review, we summarize the role of Cisd2 in human aging-related diseases and various cancers, as well as the biological functions, underlying mechanisms, and potential clinical significance.
Le texte complet de cet article est disponible en PDF.Highlights |
• | This paper reviews the recent literature on Cisd2. |
• | This paper summarizes the role of Cisd2 in human aging related diseases and on cancer field was summarized. |
• | Cisd2 is a potential biomarker of human cancer and a potential target for cancer diagnosis and treatment. |
• | This review is valuable to all who are engaged in this field. |
Keywords : CDGSH iron-sulfur domain2 (Cisd2), Senescence related, Cancer, Age-related diseases, Biomarker
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Vol 138
Article 111472- juin 2021 Retour au numéro
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