Preliminary study on the possible impact of Thalassodendron ciliatum (Forss.) den Hartog acidic polysaccharide fractions against TAA induced liver failure - 16/04/21
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Abstract |
The water-soluble acidic polysaccharide from Thalassodendron ciliatum (Forss.) den Hartog was successfully extracted, fractionated and purified. The phytochemical profile of the two water-soluble fractions (F1 and F2), were detected using different analytic techniques. GC-MS analysis revealed the presence of 22 saccharide. Acidic polysaccharide, galacturonic and glucuronic acid were the most abundant. Moreover, paper chromatography and electrophoresis also performed as a preliminary chemical characterization of the polymer. The hepatoprotective activity of the fractions against thioacetamide (TAA) induced liver failure; antioxidant potential and preliminary immunomodulatory activity were assigned in-vivo. The results revealed a potent competence to improve the liver function profile (ALT, AST, total bilirubin, total glyceride, etc.) and a remarkable improvement in liver architecture in comparison to the challenged intoxicated groups. Moreover, they showed high anti-oxidative properties and a promising immunomodulatory influence via Il6. These findings provide new insight into the possible role of polysaccharide purified two fractions in the treatment of acute liver injury.
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Highlights |
• | For the first time Thalassodendron anionic polysaccharide were studied. |
• | Moisture content, lipids content and low molecular weight carbohydrate were estimated. |
• | The polysaccharide composed of galactouronic, glucouronic, glucose and mannose, arabinose, fructose and sucrose. |
• | In-vivo study of the hepatoprotective activity, histopathology sections and liver function profile tests were performed. |
• | The polysaccharide fractions reveal a remarkable hepatoprotective activity, high anti-oxidative and immunomodulatory effect. |
Keywords : Thalassodendron ciliatum, Seagrass, Acidic polysaccharides, Antioxidant hepatoprotective, Immunomodulatory
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Vol 138
Article 111502- juin 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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