Downregulation of MMP1 expression mediates the anti-aging activity of Citrus sinensis peel extract nanoformulation in UV induced photoaging in mice - 16/04/21
, Nora M. Aborehab e, Mai F. Ragab f, Dalia Mohamed g, h, Amira Hashad b, Dalia Attia i, Maha M. Salama c, j, Mahitab H. El Bishbishy dBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Aging of the skin is a complicated bioprocess that is affected by constant exposure to ultraviolet irradiation. The application of herbal-based anti-aging creams is still the best choice for treatment. In the present study, Citrus sinensis L. fruit peels ethanolic extract (CSPE) was formulated into lipid nanoparticles (LNPs) anti-aging cream. Eight different formulations of CSEP-LNPs were prepared and optimized using 23 full factorial designs. In vivo antiaging effect of the best formula was tested in Swiss albino mice where photo-aging was induced by exposure to UV radiation. HPLC-QToF-MS/MS metabolic profiling of CSPE led to the identification of twenty-nine metabolites. CSPE was standardized to a hesperidin content of 15.53 ± 0.152 mg% using RP-HPLC. It was suggested that the optimized formulation (F7) had (245 nm) particle size, (91.065%) EE, and (91.385%) occlusive effect with a spherical and smooth surface. The visible appearance of UV-induced photoaging in mice was significantly improved after topical application on CSPE-NLC cream for 5 weeks, levels of collagen and SOD were significantly increased in CSPE- NLC group, while levels of PGE2, COX2, JNK, MDA, and elastin was reduced. Finally, The prepared anti-aging CSPE-NLC cream represents a safe, convenient, and promising skincare cosmetic product.
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Highlights |
• | Citrus sinensis L. fruit peels ethanolic extract (CSPE) was formulated into lipid nanoparticles (LNPs) anti-aging cream. |
• | HPLC-QToF-MS/MS metabolic profiling of CSPE led to the identification of twenty-nine metabolites. |
• | CSPE was standardized to a hesperidin content of 15.53 ± 0.152 mg% using RP-HPLC. |
• | Application of CSPE-NLC cream for 5 weeks increased the levels of collagen and SOD. |
• | The prepared anti-aging CSPE-NLC cream represents a safe, convenient, and promising skincare product. |
Keywords : Skin aging, Lipid nanoparticles, Factorial Design, Citrus sinensis L., Elastase, Collagenase
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Vol 138
Article 111537- juin 2021 Retour au numéro
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