Effect of hysteroscopic septum resection on subsequent in vitro fertilization–intracytoplasmic sperm injection outcomes in cases of primary infertility - 16/04/21

Doi : 10.1016/j.jogoh.2021.102149

Hui-xiao Chen, P.D ^a,^b,^c, Shang-ge Lv, M.D ^a,^b, Ya-nan Zhang, M.D ^b, Qian Yu, M.D ^b, Jing Du, M.D ^c, Lei Yan, P.D ^a,^b,^⁎ , Zi-Jiang Chen, P.D ^a,^b,^d
^a School of medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China
^b Center for Reproductive Medicine, Reproductive Hospital Affiliated to Shandong University, Jinan, Shandong, 250012, China
^c Department of Gynecology and Obstetrics, Liaocheng People's Hospital, Shandong Province, 252000, China
^d National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China

^⁎Corresponding author: Lei Yan School of medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong No.44 wenhua xi RD, Jinan 250012, Shandong, China Tel: (86)18660782393School of medicineCheeloo College of Medicine, Shandong UniversityJinan, Shandong No.44 wenhua xi RDJinanShandong250012China

Sous presse. Manuscrit accepté. Disponible en ligne depuis le Friday 16 April 2021
Cet article a été publié dans un numéro de la revue, cliquez ici pour y accéder

Highlights

•	Effect of hysteroscopic septum resection in primary infertility in IVF

Le texte complet de cet article est disponible en PDF.

Abstract

Objective

Women with septate uteri are at risk for subfertility, recurrent miscarriage, and preterm birth. It is not clear if hysteroscopic septum resection is beneficial to subsequent in vitro fertilization–intracytoplasmic sperm injection o (IVF/ICSI) outcomes in women with primary infertility.

Study Design

We analyzed all 278 women with uterine septum and primary infertility between January 2011 and January 2019. In this retrospective cohort study, the patients were divided into a surgery group and an expectant (non-surgery) group.

Results

Among them, 87 had a complete and 191 a partial septate uterus. The IVF-ET characteristics of the two groups showed no significant differences in the patients’ age, body mass index, or basal follicle-stimulating hormone, luteinizing hormone, and estradiol levels (P>0.05). The miscarriage rate in those who underwent hysteroscopic septum resection, however, was significantly reduced (5.1% vs. 12.9%, P=0.035). In contrast, the live birth rate between the two groups revealed no significant difference (51.4% vs. 43.6%, P=0.1771), nor did the obstetric and neonatal outcomes (P>0.05).