HBV-infection rate and long-term outcome after liver-transplantation of anti-HBc-positive liver-grafts to HBV-naïve recipients: A retrospective study - 20/04/21
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 9 |
| Iconographies | 5 |
| Vidéos | 0 |
| Autres | 0 |
Highlights |
• | Long-term outcome of HBV-naive patients receiving Anti-HBc-positive liver grafts is similar to Anti-HBc-negative graft recipients. |
• | Antiviral prophylaxis can successfully prevent HBV infection of Anti-HBc-positive liver graft recipients depending on the prophylaxis regimen. |
• | No HBV infection occured in patients with prophylaxis regimens consisting of modern nucleoside analogues alone. |
Abstract |
Background |
Anti-HBc only positive liver grafts may be suitable for HBV-naive recipients insofar as an appropriate infection prophylaxis is performed. Therefore, we investigated the effect of prophylactic regimens on HBV infection prevention and long-term outcome of anti-HBc-positive graft recipients.
Patients and methods |
This retrospective monocenter study consisted of a cohort of 1912 patients who underwent deceased donor liver transplantation at our transplant center between June 1987 and July 2019. 81 HBV-naïve patients after reception of an anti-HBc-positive liver-graft and consecutive HBV prophylaxis were selected for further examination. HBV infection rate and host- and graft-survival rates were compared to a matched control group consisting of 162 HBV-naïve patients after reception of anti-HBc-negative grafts. Pharmaceutical HBV prophylaxis included: only HBIG, only NUCs, or combined HBIG and NUCs.
Results |
Compared to control cases of HBV-naïve anti-HBc-negative graft recipients, no differences in host- and graft-survival rate were determined.13 of 81 anti-HBc-positive graft recipients (16%) developed HBV-infection after liver transplantation. No patient suffered from HBV infection after receiving modern NUCs. Survival analysis showed no statistical differences between patients with and without infection concerning host- and graft-survival.
Conclusion |
Especially in times of organ shortage, anti-HBc-positive liver grafts may be useful for liver transplantation in HBV-naïve recipients. Efficient prophylactic regimens can prevent HBV-infection.
Le texte complet de cet article est disponible en PDF.Abbreviations : LT, HCC, PSC, HBIG, NUC, HBV, HBs, HBc, HCV
Keywords : Liver transplantation, Hepatitis B, HBV-infection, anti-HBc-positive liver-grafts, HBIG, Nucleoside analogue, Nucleotide analogue
Plan
Vol 45 - N° 2
Article 101496- mars 2021 Retour au numéro
Article précédent
- The dynamic of platelet count as a novel and valuable predictor for 90-day survival of hepatitis B virus-related acute-on-chronic liver failure patients
- Xuwen Xu, Zhouhua Hou, Yuyuan Xu, Huimin Gu, Guangyu Liang, Yukun Huang
- Prevalence and molecular characterization of hepatitis B virus infection in HIV-infected children in Senegal
- Rayana Maryse Toyé, Gora Lô, Halimatou Diop-Ndiaye, Abdoul Magib Cissé, Anna Julienne Selbé Ndiaye, Khady Kébé-Fall, Aboubakri Dramé, Damien Cohen, Flor Helene Pujol, Souleymane Mboup, Cheikh Saad Boye, Isabelle Chemin, Gabrièle Laborde-Balen, Bernard Taverne, Coumba Touré-Kane
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?