The clinical, prognostic and therapeutic significance of liver cancer stem cells and their markers - 14/05/21
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Summary |
Hepatocellular carcinoma (HCC) is the fourth most common cause of death among cancers. The poor prognosis of HCC might be caused by a population of cancer stem cells (CSC). CSC have similar characteristics to normal stem cells and are responsible for cancer recurrence, chemoresistance, radioresistance and metastasis. Liver cancer stem cells (LCSC) are identified via specific surface markers, such as CD44, CD90, CD133, and EpCAM (CD326). Recent studies suggested a complex interaction between mentioned LCSC markers and clinical features of HCC. A high expression of CSC is correlated with a negative prognostic factor after surgical resection of HCC and is connected with more aggressive tumor behavior. Moreover, LCSC might be responsible for increasing resistance to sorafenib, a kinase inhibitor drug. A reduction in the LCSC population may be crucial to successful advanced HCC therapy.
Le texte complet de cet article est disponible en PDF.Keywords : Hepatocellular carcinoma, Liver cancer stem cells, Prognostic factors
Plan
Vol 45 - N° 3
Article 101664- mai 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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