Leptin serum level is associated with clinical outcome after STEMI - 18/05/21
Résumé |
Introduction |
Leptin, an adipocyte derived hormone, plays a central role in food intake regulation but also in inflammation regulation. Leptin level is increased after myocardial infarction but its relationship with clinical prognosis is unknown.
Objective |
The study objective was to evaluate, in a cohort of patients admitted for ST elevation myocardial infarction (STEMI), the one-month serum kinetics of leptin and its potential relationship with infarct size, left ventricular function and clinical outcome.
Methods |
We prospectively enrolled 251 consecutive STEMI patients. Leptin was assessed in the serum at admission (H0), 4h, 24h and 48hours (H4, H24 and H48) and 1month (M1) after admission. Patients underwent cardiac magnetic resonance imaging at M1 for measurement of infarct size (IS) and left ventricular ejection fraction (LVEF). Clinical outcomes were recorded over 24months after STEMI.
Results |
We demonstrated that leptin level reaches a peak 24hours after the admission. Leptin level at H24 was correlated with IS (r=0.19, P=0.02) and inversely correlated with LVEF (r=−0.16, P=0.04). Leptin serum level was associated with an increased risk of experiencing the composite endpoint during the 24months of follow-up [adjusted HR=2.3 CI (1.1–4.8), P=0.03].
Conclusion |
These results suggest that leptin might be an early prognosis marker in STEMI patients.
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Vol 13 - N° 2
P. 196 - mai 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.