Real Time Intraoperative Functional Brain Mapping Based on RGB Imaging - 22/05/21
pages | 9 |
Iconographies | 6 |
Vidéos | 0 |
Autres | 0 |
Graphical abstract |
Highlights |
• | Optical imaging is particularly adapted for intraoperative translational works. |
• | The brain activity can be monitored with the quantification of cortical hemoglobin. |
• | A functional model was implemented to identify the activated cortical areas. |
• | Patient's cortical activity is monitored in real time (during data acquisition). |
Abstract |
Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. However, it still lacks robustness to be used as a clinical standard. In particular new biomarkers of brain functionality with improved sensitivity and specificity are needed. We present a method for the real time identification of the activated cortical areas based on the analysis of the cortical hemodynamic using a RGB camera and a white light source. We measure the quantitative oxy and deoxy-hemoglobin concentration changes in the human brain cortex with the modified Beer-Lambert law and Monte Carlo simulations. A functional model has been implemented to define in real time a binary biomarker of the cortical activation following neuronal activation by physiological stimuli. The results show a good correlation between the computed activation maps and the brain areas localized by electrical brain stimulation. We demonstrate that a RGB camera combined with a quantitative modeling of brain hemodynamics biomarkers can evaluate in real time the functional areas during neurosurgery and serve as a tool of choice to complement electrical brain stimulation.
Le texte complet de cet article est disponible en PDF.Keywords : Functional brain mapping, Real time processing, Intraoperative imaging, Optical imaging, RGB camera
Plan
Vol 42 - N° 3
P. 189-197 - juin 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?