Live birth rates in different subgroups of poor ovarian responders according to Bologna and POSEIDON group classification criteria - 24/05/21

Doi : 10.1016/j.jogoh.2021.102169

Mehri Mashayekhy ^a,^⁎ , Forouzan Barabi ^a, Arezoo Arabipoor ^a,^⁎ , Zahra Zolfaghari ^b,^c
^a Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
^b Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
^c Department of Diabetes, Obesity and Metabolism, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran

^⁎Corresponding Authors: Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, P.O. Box: 19395-4644, No. 12, East Hafez Avenue, Banihashem Street, Resalat Highway, Tehran, Iran. Tel: +982123562640, Fax: +982122306481Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research CenterP.O. Box: 19395-4644, No. 12, East Hafez Avenue, Banihashem Street, Resalat HighwayTehranIran^⁎⁎Corresponding author.

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Abstract

Purpose

The present study was designed to compare the live birth rates (LBRs) according to Bologna criteria or Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number (POSEIDON) group classifications to determine the important predictive factors for LBR in patients with POR.

Basic procedures

In this cross-sectional study, the database of Royan Institute (Tehran, Iran) from December 2015 to December 2017 was evaluated and the fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles outcomes for all the patients with at least one POR after standard controlled ovarian stimulation were collected. The patients divided into five subgroups according to Bologna criteria and four groups on the basis of POSEIDON group classification.

Main finding

812 patients with POR diagnosis were assessed which 517 (63.6%) of them were underwent embryo transfer (ET) during the last treatment cycle. According to Bologna criteria, 41 patients were not included in any subgroup and the patients in Bologna group II had highest LBR (19.8%). In terms of POSEIDON classification, all of the patients were classified into subgroups and the women in POSEIDON group III had the highest LBR (27%). According to multivariable regression analysis, the significant independent predictive factors for LBR were the number and morphology (good and excellent) of the embryos transferred, and POSEIDON group III classification.

Principal conclusion

The results indicated that the POSEIDON group classification could be more comprehensive and practical than Bologna criteria for categorizing POR patients and predicting their outcome. Moreover, the number and morphology of transferred embryos were the most important prognostic factors for live births in these patients.

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Keywords : Poor ovarian responders, Live birth rate, Bologna criteria, POSEIDON group classification