Novel and emerging mutations of SARS-CoV-2: Biomedical implications - 02/06/21

Doi : 10.1016/j.biopha.2021.111599

Elmira Mohammadi ^a,^b, Fatemeh Shafiee ^c, Kiana Shahzamani ^d, Mohammad Mehdi Ranjbar ^e, Abbas Alibakhshi ^f, Shahrzad Ahangarzadeh ^g,^⁎ , Leila Beikmohammadi ^h, Laleh Shariati ^h,ⁱ, Soodeh Hooshmandi ^k, Behrooz Ataei ^g, Shaghayegh Haghjooy Javanmard ^j
^a Applied Physiology Research Center, Cardiovascular Research Institute, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
^b Core Research Facilities, Isfahan University of Medical Sciences, Isfahan, Iran
^c Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
^d Isfahan Gastroenterology and Hepatology Research Center (lGHRC), Isfahan University of medical sciences, Isfahan, Iran
^e Razi Vaccine and Serum Research Institute, Agricultural Research, Education, and Extension Organization (AREEO), Karaj, Iran
^f Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
^g Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
^h Department of Biochemistry, Erasmus University Medical Center, Rotterdam, The Netherlands
ⁱ Stem Cell and Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, 14155-6559 Tehran, Iran
^j Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
^k Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

^⁎Corresponding author.

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Abstract

Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19.

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Keywords : SARS-CoV-2, COVID-19, Mutation, Genetic variation, Spike protein

Plan

Introduction

Evolution of viruses and mechanisms of viral mutation

Genetic material of SARS-CoV-2

Types of variation in SARS-CoV-2

Variant analysis of SARS-CoV-2 genome

Classification of routine missense variants in clades

Transition versus transversion mutations

Very common mutations in the SARS-CoV-2 genome

Geographic distribution of SARS-CoV-2 mutations

Conclusion and future perspectives

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Vol 139

Article 111599- juillet 2021 Retour au numéro

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Novel and emerging mutations of SARS-CoV-2: Biomedical implications - 02/06/21

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