Correlation between magnetic resonance imaging characteristics and BRAF alteration status in individuals with optic pathway/hypothalamic pilocytic astrocytomas - 03/06/21
, Shigeru Yamaguchi ⁎ , Michiharu Yoshida , Hiroaki Motegi , Hiroyuki Kobayashi , Shunsuke Terasaka , Kiyohiro Houkin Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Résumé |
Graphical abstract |
Highlights |
• | Optic pathway/hypothalamic pilocytic astrocytoma (OPHPA) harboring BRAF fusion present higher T2 signal intensity on T2 weighted imaging of MRI. |
• | OPHPA harboring BRAF V600E mutation present larger mismatch between hyperintense area on FLAIR and contrast enhanced area on gadolinium-enhanced T1 weighted imaging. |
• | BRAF alternation status in OPHPA is associated with preoperative MRI findings. |
Abstract |
Background and purpose |
Most individuals with optic pathway/hypothalamic pilocytic astrocytoma (OPHPA) harbor either the BRAF V600E mutation or KIAA1549-BRAF fusion (K-B). This study aimed to investigate the imaging characteristics of OPHPA in relation to BRAF alteration status.
Materials and methods |
Seven cases of OPHPA harboring either the BRAF V600E mutation or K-B fusion were included in the study. Preoperative magnetic resonance imaging (MRI) was assessed for degree of T2 hyperintensity on T2-weighted images (T2WI) and the ratio of nonenhancing T2 or fluid-attenuated inversion recovery (FLAIR) hyperintense area to the contrast enhanced area (CE) on gadolinium-enhanced-T1 weighted images (T2/FLAIR-CE mismatch). The T2 signal intensity was normalized to cerebrospinal fluid (T2/CSF) for both the V600E and K-B group and compared. T2/FLAIR-CE mismatch was assessed by calculating the proportion of the tumor volume of nonenhancing high T2 signal intensity to the whole lesion (nonenhancing and enhancing components).
Results |
Four and three cases of OPHPA harboring the BRAF V600E mutation and K-B, respectively, were analyzed. The T2/CSF value was higher in the K-B group than in the V600E group. Moreover, the V600E group had a larger T2/FLAIR-CE mismatch than the K-B group.
Conclusions |
The BRAF alteration status in individuals with OPHPA was associated with preoperative MRI by focusing on T2 signal intensity and T2/FLAIR-CE mismatch. The BRAF V600E mutation was associated with a lower T2/CSF value and larger T2/FLAIR-CE mismatch, whereas K-B fusion was associated with a higher T2/CSF value and smaller T2/FLAIR-CE mismatch.
Le texte complet de cet article est disponible en PDF.Keywords : Optic pathway, Hypothalamic, Pilocytic astrocytoma, BRAF V600E, KIAA1549-BRAF fusion, MRI
Abbreviations : CE, CSF, ex, FLAIR, Gd, K-B, MRI, OPHPA, PA, PCR, ROI, RT-PCR, WHO, WI
Plan
Vol 48 - N° 4
P. 266-270 - juin 2021 Retour au numéro
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