Epidemiology of cutaneous involvement in Sjögren syndrome: Data from three French pSS populations (TEARS, ASSESS, diapSS) - 05/06/21
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Highlights |
• | Cutaneous involvement is common during primary Sjögren syndrome (pSS), but prevalence and characteristics are difficult to establish. |
• | The most common cutaneous involvement of pSS is skin dryness (evaluated by VAS). |
• | Other dermatological signs of pSS are rare but associated with ESSDAI activity in other domains. |
Abstract |
Objective |
To determine the prevalence and significance of dermatological disorders in primary Sjögren syndrome (pSS).
Methods |
We used 2 pSS French cohorts (ASSESS, in which prevalence of skin disorders in 395 patients was evaluated; and diapSS, in which 76 on 139 pSS patients had an examination by a dermatologist) and baseline data of the TEARS randomized trial (110 patients with recent or active pSS treated with rituximab or placebo and evaluated for skin dryness using a visual analogue scale (VAS) out of 100).
Results |
Skin manifestations included in the EULAR Sjögren syndrome disease activity index (ESSDAI) were rare in the ASSESS cohort (n=16/395, 4.1%, mainly purpuras; only 3 had high activity), but they were associated with activity in the other ESSDAI domains (peripheral neurological (P<0.001), muscular (P<0.01), haematological (P<0.05), biological (P<0.05), history of arthritis (P<0.01), splenomegaly (P<0.05) and higher gamma globulin levels (P<0.01)). In the diapSS cohort, compared to pSS patients not receiving a dermatological consultation, the pSS patients who had a dermatological consultation had significantly more dermatological involvement outside the ESSDAI score [38.2% (29/76) versus 15.9% (10/63); P<0.01]. The TEARS study showed a high prevalence of cutaneous dryness (VAS>50; 48.2%) and found that patients with dry skin had higher VAS pain (P<0.01) and drought (P<0.01) scores.
Conclusion |
ESSDAI skin activity is rare and associated with hypergammaglobulinemia and ESSDAI activity. Systematic dermatological examination is informative for non-specific lesions. The most common skin disorder is skin dryness, which is associated with a higher pain and overall subjective dryness.
Le texte complet de cet article est disponible en PDF.Keywords : Skin, Cutaneous involvement, Dryness, Sicca, Sjogren syndrome, Disease activity, Visual analogic score, Rheumatology, Cohort, Rituximab
Plan
Vol 88 - N° 4
Article 105162- juillet 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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