Influence of prognosis factors on the prescription of targeted treatments in rheumatoid arthritis: A Delphi survey - 05/06/21
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Highlights |
• | It is unclear whether rheumatologist takes into account specific poor prognostic factors when deciding a treatment beyond classic DMARDs in RA. |
• | The effect of currently available bDMARDs and JAK inhibitors on the classically accepted poor prognostic factors of RA is unclear. |
• | By a two-round Delphi to practising rheumatologists we found that the only prognostic factor that significantly influenced the selection of treatment was the presence of interstitial lung disease (ILD), being the preferred treatment in this scenario abatacept or rituximab. |
• | There is no solid evidence regarding the use of any specific therapy in the management of patients with specific poor factors, except in the case of RA-ILD, although the evidence in this regard is not free of bias. |
Abstract |
Objectives |
To explore current evidence on the management of poor prognostic factors in rheumatoid arthritis (RA) and to investigate whether this evidence is taken into account by clinicians when deciding on treatment in daily clinical practice.
Methods |
We performed a systematic literature review (SLR) to analyse the effects of currently available biologic disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitors (JAKi) on the classically accepted poor prognostic factors of RA. All randomized controlled trials reporting subgroup analyses about effects on prognostic factors were identified and synthesized. In a second phase, a two-round Delphi survey was carried out to contrast the SLR results with the grade of agreement of a large group of rheumatologists about the effectiveness of each drug class on each prognostic factor.
Results |
According to the Delphi results, the only prognostic factor that significantly influenced the selection of treatment was the presence of interstitial lung disease (ILD), being the preferred treatment in this scenario abatacept or rituximab. The rest of the poor prognostic factors (including high disease activity at baseline, disability as measured by the Health Assessment Questionnaire index, seropositivity, elevated acute-phase reactants, and evidence of erosions based on plain radiography or ultrasonography) did not seem to significantly influence rheumatologists when choosing a treatment. The results of the SLR results did not show solid evidence regarding the use of any specific therapy in the management of patients with specific poor factors, except in the case of RA-ILD, although the data in the literature in this regard are not free of bias.
Conclusions |
The only prognostic factor that seems to significantly influence the selection of treatment is the presence of RA-ILD.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid arthritis, Prognosis, Delphi, Systematic review
Plan
Vol 88 - N° 4
Article 105172- juillet 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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