Impact of sarcopenia on clinical outcomes of patients undergoing simultaneous liver and kidney transplantation: a cohort study - 16/06/21
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Iconographies | 7 |
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Autres | 0 |
Highlights |
• | Sarcopenia is associated with an increased risk of infections and mortality post-LT. |
• | No data are available on the impact of sarcopenia in SLKT recipients. |
• | Sarcopenia threshold was defined as TPA < 1460 mm2 (women) and <1560 mm2 (men). |
• | Prospective and multi-centre studies are needed to evaluate frailty in this population. |
Abstract |
Background |
The impact of sarcopenia in patients undergoing simultaneous liver and kidney transplantation (SLKT) has not been fully delineated. The aim of this single-centre-cohort-study was to evaluate the impact of sarcopenia on the clinical outcomes.
Methods |
Between 2003 and 2018, 79 patients underwent SLKT. Sarcopenia was assessed via the total psoas muscle area (TPA) at the level of the 3rd. lumbar vertebra. Sarcopenia threshold was TPA < 1460 mm2 (women) and <1560 mm2 (men). We identified post-operative biliary, vascular and digestive complications. Survival analysis was performed by the Kaplan Meier method (log-rank test).
Results |
We included 43/79 SLKT recipients (56%male, median age of 58 [53−63] years). The prevalence of cirrhosis was 74% (n = 32) with median MELD-score of 21 (20−22) and that of polycystic-liver-disease was 26% (n = 11). End-stage-renal-disease of unknown origin was 36.2% (n = 12). Dialysis before transplantation was performed in 54,8% (n = 23) of patients. The median TPA was 1138 (926−1510) mm2, and sarcopenia was detected in 72% of patients (n = 31). No difference in patient or death-censored graft-survival between sarcopenic and non-sarcopenic groups at 1 year was reported. Also, no differences at 6-months’ post-transplant-complication-free and infection-free-survival rates were found.
Conclusion |
In this cohort of patients, no differences were observed in patients, grafts, complications or infection-free survival between sarcopenic or no sarcopenic SLKT patients. Future multi-centre studies are needed to validate and extend the generalisability of these findings.
Le texte complet de cet article est disponible en PDF.Abbreviations : SLKT
Keywords : Liver transplantation, Kidney transplantation, Sarcopenia, Infection, Postoperative complication, Long-term outcomes
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Vol 45 - N° 4
Article 101692- juillet 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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