Baicalein alleviates depression-like behavior in rotenone- induced Parkinson's disease model in mice through activating the BDNF/TrkB/CREB pathway - 17/06/21
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 11 |
| Iconographies | 10 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Background |
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in the world. In addition to motor symptoms, a variety of non-motor symptoms seriously affect the life quality of PD patients. Baicalein, a flavonoid extracted from the herb Scutellaria baicalensis Georgi, exhibits anti-PD activity through alleviation of its motor symptoms. However, its effects on non-motor symptoms were barely reported. This study aimed to investigate the therapeutic effects of baicalein on PD-related depression.
Methods |
After a 2-week injection of rotenone, mice with PD-related depression behavior were selected, divided into three groups, and administrated saline, baicalein, or madopar orally for four weeks. Behavior, neuroinflammation, neurotransmitters, and synaptic plasticity were evaluated.
Results |
Our results showed that 4-week baicalein treatment significantly alleviated the depression-like behavior in the rotenone-induced mice model. Repeated baicalein treatment reduced α-synuclein aggregation, inhibited neuroinflammation, and maintained neurotransmitters homeostasis. Moreover, we found that baicalein treatment could remarkably protect the synaptic plasticity and activate the BDNF/TrkB/CREB pathway in the PD-related depression mice model. As traditional dopamine replacement therapy unleashed few effects on depression-like symptom amelioration and synaptic function protection, baicalein might be a more appropriate choice for PD-related depression.
Conclusions |
The current results suggested that baicalein could act as a treatment for PD-related depression.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | The rotenone-induced PD-related depression mice is valuable for drug discovery. |
• | Baicalein attenuated depression-like symptom in rotenone-induced PD mice model. |
• | Baicalein reduced α-synuclein toxicity and neuroinflammation damage. |
• | Baicalein maintained the homeostasis of monoamine neurotransmitters. |
• | Baicalein protected synaptic plasticity through BDNF/TrkB/CREB pathway. |
Abbreviation : PD, BDNF, TrkB, CREB, GFAP, Iba1, DA, DOPAC, HVA, 5-HT, 5-HITT, NE, PCA, PSD95, SYP, PI3K, CaMK Ⅱ, ROS
Keywords : Parkinson’s disease, Depression, Rotenone, Baicalein, BDNF
Plan
Vol 140
Article 111556- août 2021 Retour au numéro
Article précédent
- Probiotic-prebiotic-synbiotic modulation of (YAP1, LATS1 and NF2 mRNAs/miR-1205/lncRNA SRD5A3-AS1) panel in NASH animal model
- Shaimaa H. Gadallah, Sanaa Eissa, Hala M. Ghanem, Emad K. Ahmed, Amany Helmy Hasanin, Manal M. El Mahdy, Marwa Matboli
- Anti-inflammatory activity of Jasminum grandiflorum L. subsp. floribundum (Oleaceae) in inflammatory bowel disease and arthritis models
- Riham A. El-Shiekh, Dorria Hussein, Attia H. Atta, Samar M. Mounier, Mohamed R. Mousa, Essam Abdel-Sattar
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?