Pioglitazone rescues high-fat diet-induced depression-like phenotypes and hippocampal astrocytic deficits in mice - 17/06/21
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Abstract |
The prevalence of diabetes is rapidly increasing worldwide and is highly associated with the incidence of depression. Pioglitazone, a Peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, is widely used for treating patients with type 2 diabetes. However, whether pioglitazone alleviates metabolic disorder-related depression and astrocytic deficits remains unclear. Here we showed that 12 weeks of high-fat diet (HFD) feeding (from 8- to 20-week-old) induced not only obesity and insulin resistance, but also depression-like behaviors in mice. Astrocytic activation, a sign closely associated with depression, was also evident in the ventral hippocampus. Four weeks of pioglitazone (10 or 20 mg/kg, daily, from 20- to 24-week-old) treatment alleviated the HFD-induced glucose-metabolic dysfunctions, upregulation of ventral hippocampal GFAP, reduction of the total process lengths and the number of branch points of the ventral hippocampal CA1 GFAP-immunoreactive astrocytes and depressive phenotypes but had no effect on anxiety-like behaviors or hippocampus-related learning and memory in mice. These findings suggest that pioglitazone could be a potential therapeutic agent for metabolic disorders and associated depression.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Pioglitazone alleviated high-fat diet (HDF)-induced depressive phenotypes in mice. |
• | Pioglitazone reduced the HFD-induced upregulation of GFAP in hippocampal astrocytes. |
• | Pioglitazone rescued HFD-disturbed the morphology of the hippocampal astrocytes. |
Keywords : Astrocyte, Antidepressant, Diabetes, Obesity, Thiazolidinedione
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Vol 140
Article 111734- août 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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