Novel advances in inhibiting advanced glycation end product formation using natural compounds - 17/06/21
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Abstract |
Advanced glycation end products (AGEs) are a group of complex compounds generated by nonenzymatic interactions between proteins and reducing sugars or lipids. AGEs accumulate in vivo and activate various signaling pathways closely related to the occurrence of various chronic metabolic diseases. In this paper, we describe the process through which AGEs are formed, the classification of AGEs, and biological effects of AGEs on human health. Most importantly, we review recent progress in natural compound-based AGE formation inhibitors. Major classes of natural inhibitors, including polyphenols, polysaccharides, terpenoids, vitamins and alkaloids, have been described. Their mechanisms of action have been summarized as scavenging free radicals, chelating metal ions, capturing active carbonyl compounds, protecting protein glycation sites, and lowering blood glucose levels. Although these natural compounds have good antiglycation activity, to date, they are not widely used in the clinic, likely because of their low content levels. However, these natural compounds and their molecular frameworks will play a valuable role in inspiring drug discovery.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | The formation, classification and biological activity of AGEs are described. |
• | Some natural compounds are good candidates for natural glycation inhibitors. |
• | Seven mechanisms that inhibit the formation of AGEs of natural glycation inhibitors are summarized. |
• | These natural compounds will play a valuable role in inspiring drug discovery. |
Keywords : Advanced glycation end products, Antiglycation, Natural compounds, AGE formation inhibitors
Plan
Vol 140
Article 111750- août 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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