Biosynthetic versatility of marine-derived fungi on the delivery of novel antibacterial agents against priority pathogens - 17/06/21
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Abstract |
Despite the increasing number of novel marine natural products being reported from fungi in the last three decades, to date only the broad-spectrum cephalosporin C can be tracked back as marine fungal-derived drug. Cephalosporins were isolated in the early 1940s from a strain of Acremonium chrysogenum obtained in a sample collected in sewage water in the Sardinian coast, preliminary findings allowing the discovery of cephalosporin C. Since then, bioprospection of marine fungi has been enabling the identification of several metabolites with antibacterial effects, many of which proving to be active against multi-drug resistant strains, available data suggesting also that some might fuel the pharmaceutical firepower towards some of the bacterial pathogens classified as a priority by the World Health Organization. Considering the success of their terrestrial counterparts on the discovery and development of several antibiotics that are nowadays used in the clinical setting, marine fungi obviously come into mind as producers of new prototypes to counteract antibiotic-resistant bacteria that are no longer responding to available treatments. We mainly aim to provide a snapshot on those metabolites that are likely to proceed to advanced preclinical development, not only based on their antibacterial potency, but also considering their targets and modes of action, and activity against priority pathogens.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Critical analysis on 108 antibacterial agents isolated from marine fungi. |
• | Metabolites are highlighted considering chemical novelty and antibacterial potency. |
• | The number of pre-clinical candidates against WHO Priority pathogens remains scarce. |
• | Several metabolites call for further development as future antibiotic candidates. |
• | Challenges dealing with antibiotic discovery from marine fungi are stressed out. |
Keywords : Aspergillus, Escherichia coli, Infectious diseases, Penicillium, Pseudomonas aeruginosa, Staphylococcus aureus
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Vol 140
Article 111756- août 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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