A qualitative and quantitative comparison of Crocus sativus and Nigella sativa immunomodulatory effects - 17/06/21
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Abstract |
The present article reviews and compares the immunomodulatory activities of Crocus sativus (C. sativus) and Nigella sativa (N. sativa) and their main bioactive compounds. Immunomodulatory effects of these plants, especially with respect to Th1 and Th2 cytokines, are discussed based on relevant articles, books, and conference papers published in English until the end of April 2020, that were retrieved from Web of Science, PubMed, Scopus and Google Scholar databases. C. sativus and its constituents increase immunoglobulin (Ig-)G, interleukin 2 (IL)-2, interferon gamma (IFN-γ), and IFN-γ/IL-4 ratio, but decreased IgM, IL-10 and IL-4 secretion. N. sativa extract and thymoquinone reduce the levels of IL-2, -4, -10, and -12, while enhance IFN-γ and serum IgG1 and 2a.
The reviewed articles indicate that C. sativus and N. sativa and their constituents could be potentially considered promising treatments for disorders associated with immune-dysregulation such as asthma and cancer.
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Highlights |
• | Immunomodulatory activities of Crocus sativus, Nigela sativa and their compounds were presented. |
• | C. sativus and its ingredients increased levels of Ig-G, IL-2, and IFN-γ. |
• | C. sativus and its constituents decreased IgM, IL-10 and IL-4 secretion. |
• | N. sativa extract and thymoquinone (TQ) reduced the levels of IL-2, -4, -10, and -12. |
• | N. sativa extract and TQ enhanced the level of IFN-γ, and serum levels of IgG1 and 2a. |
Keywords : The immune system, Crocus sativus, Nigella sativa, Safranal, Crocin, Kaempferol, Black seed
Plan
Vol 140
Article 111774- août 2021 Retour au numéro
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