Chronic kidney disease consecutive to chemotherapy for chondroblastic osteosarcoma: A report on 6 pediatric cases - 04/07/21
, Anita Duncan a, Justine Bacchetta a, b, Laurence Dubourg b, c, Perrine Marec-Bérard d, Corentin Tanné eCet article a été publié dans un numéro de la revue, cliquez ici pour y accéder
Abstract |
Background |
The management of osteosarcoma in children and adolescents is based on poly-chemotherapy including several nephrotoxic drugs (e.g. ifosfamide, methotrexate, and cisplatinum). Chronic renal toxicity is a frequent complication but stage 5 chronic kidney disease requiring dialysis is rare. We report here a series of six pediatric patients with osteosarcoma displaying chronic kidney disease after chemotherapy.
Case-diagnosis/treatment |
We retrospectively reviewed the medical charts, mainly for clinical history, timing between chemotherapy and development of tubulopathy and CKD, type of therapies and global evolution (chronic dialysis and further renal transplantation, n=2; death, n=1). Notably, all patients suffered from chondroblastic osteosarcoma.
Conclusions |
Advanced chronic kidney disease can be a complication of osteosarcoma management that could more frequently lead to dialysis and further transplantation. It would be interesting to identify specific risk factors of such renal toxicity. The chondroblastic sub-type may be associated with such susceptibility, but this needs to be confirmed.
Le texte complet de cet article est disponible en PDF.Keywords : Chondroblastic osteosarcoma, Chronic kidney disease, Glomerular toxicity, Ifosfamide, Nephrotoxicity, Pediatric tumor
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