Secondary thrombocytopenia after SARS-CoV-2 vaccine: Report of a case of hemorrhage and hematoma after minor oral surgery - 29/07/21

Doi : 10.1016/j.jormas.2021.07.010

Luigi Angelo Vaira ^a,^b,^⁎ , Luigi Podda ^c, Piero Doneddu ^a, Maria Grazia Careddu ^c, Claudio Fozza ^c,^d, Giacomo De Riu ^a
^a Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari (Head: Prof. Giacomo De Riu), Italy
^b Biomedical Science PhD School, Biomedical Science Department, University of Sassari (Head: Prof. Margherita Maioli), Italy
^c Blood Disease Operative Unit, University Hospital of Sassari, (Head: Prof. Claudio Fozza), Italy
^d Blood Disease Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, (Head: Prof. Claudio Fozza), Italy

^⁎Corresponding author at: Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari (Head: Prof. Giacomo De Riu), Viale San Pietro, 07100 Sassari, Italy.Maxillofacial Surgery Operative UnitDepartment of MedicalSurgical and Experimental SciencesUniversity of Sassari (Head: Prof. Giacomo De Riu)Viale San PietroSassari07100Italy

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Abstract

The authors present the case of a patient who underwent the removal of a small bluish lesion of the cheek. After discharge, the patient presented with profuse bleeding and hematoma of the cheek. Blood tests revealed severe secondary immune thrombocytopenia (SITP). SITP was probably triggered by the anti-SARS-CoV-2 Pfizer vaccine, which was inoculated to the patient 3 days before the lesion appeared and 12 days before surgery. The authors' aim is to inform colleagues about this possible, rare, adverse effect of the vaccine. In all patients who have recently undergone the COVID-19 vaccine and who present lesions suspected to be due to blood extravasation of the oral mucosa or unjustified gingival bleeding it is advisable to request a blood count before surgery.

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Keywords : SARS-CoV-2, Coronavirus, Vaccine, Thrombocytopenia, Secondary thrombocytopenia, Oral surgery, COVID-19