Abnormal MRI findings of the orbital or visual pathways in patients with severe COVID-19: Observations from the French multicenter COVID-19 cohort - 17/09/21
, François Cotton b, Francois Lersy c, Stéphane Kremer c, Françoise Héran a, don behalf of the
SFNR's COVID study group
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Highlights |
• | Abnormal MRI findings of the orbit or visual pathways were detected in 13% of patients with severe COVID-19. |
• | Abnormal signal on FLAIR-WI of at least one of the visual pathway structures was detected in 35% of patients. |
• | FLAIR-WI hyperintense optic disc was visible in 65% of patients. |
Abstract |
Objectives |
COVID-19 is a multisystemic disease. Ophthalmological abnormalities are relatively rare among COVID-19-infected patients. The aim of our study was to report orbital and visual pathways MRI findings in a nationwide multicenter cohort of patients with severe COVID-19.
Methods |
This IRB-approved retrospective multi-center study included participants presenting with severe COVID-19, who underwent brain MRI from March 4th to May 1st 2020. Two neuroradiologists (“blinded”), blinded to all data, individually analyzed morphological MRIs focusing on the orbits and the visual pathways. A second consensus reading session was performed in the case of disagreement between both readers. Clinical and ophthalmological data were compared to MRI findings. Descriptive statistical analysis and interobserver agreement for MRI reading using non-weighted Cohen kappa statistics were performed.
Results |
129 participants (43 [33%] women and 86 [67%] men, mean age 63 ± 14 years) were included in the study. 17/129 (13%) patients had abnormal MRI findings of the orbit or visual pathways. 11/17 (65%) patients had a FLAIR-WI hyperintense optic disc. 6/17 (35%) patients had abnormal signal of at least one of the visual pathway structures: 6/6 (100%) of the optic nerve, 1/6 (17%) of the optic chiasm, 2/6 (33%) of the optic tract and 1/6 (17%) of the optic radiations.
Conclusions |
Our study showed that a substantial number of patients with severe COVID-19 presented with abnormal MRI findings of the orbit or visual pathways, which might lead to potentially severe visual impairment.
Le texte complet de cet article est disponible en PDF.Keywords : MRI, Orbit, COVID-19, SARS-CoV-2
Abbreviations and Acronyms : MRI, SARS-CoV-2, OCT, FLAIR, RT-PCR
Plan
| Financial Support: None |
Vol 48 - N° 5
P. 331-336 - septembre 2021 Retour au numéro
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