Pathogenetic analysis of polycystic ovary syndrome from the perspective of omics - 18/09/21
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Abstract |
Polycystic ovary syndrome (PCOS) is the most common gynecological endocrine disease, involving multiple genes, multiple pathways, and complex hormone secretion processes. Hence, the pathogenesis of PCOS cannot be explained by a single factor. Omics analysis includes genomics, transcriptomics, and proteomics, which are fast and effective methods for studying the pathogenesis of diseases. PCOS is primarily characterized by androgen excess, and reproductive and metabolic dysfunctions. The application of omics analysis in the body fluids, blood, cells or tissues of women with PCOS offers the potential for unexpected molecular advantages in explaining new mechanisms of PCOS etiology and pathophysiology, and provides new perspectives for identifying potential biomarkers and developing new therapeutic targets. At present, several omics analyses have been applied to produce complex datasets. In this manuscript, the recent advances in omics research on PCOS are summarized, aiming at an important and parallel review of the newly published research.
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Highlights |
• | Various SNPs play critical roles in the pathogenesis of PCOS. |
• | Abnormal expression of microRNAs and lnc-RNAs may lead to dysfunctional GCs. |
• | Potential biomarkers for PCOS are identified by proteomics analysis. |
• | The pathogenesis of PCOS is explained through several signaling pathways. |
Keywords : PCOS, Genomics, Transcriptomics, Proteomics
Plan
Vol 142
Article 112031- octobre 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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