Osteoarthritis: From upcoming treatments to treatments yet to come - 26/09/21

Doi : 10.1016/j.jbspin.2021.105206

Vianney Delplace ^a,^b, Marie-Astrid Boutet ^a,^b,^e, Catherine Le Visage ^a,^b, Yves Maugars ^a,^c,^d, Jérôme Guicheux ^a,^b,^d,^{^{1
Co-last author.},}⁎ , Claire Vinatier ^a,^b,^{^{1
Co-last author.}}
^a Inserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, ONIRIS, 44000 Nantes, France
^b Université de Nantes, UFR Odontologie, 44042 Nantes, France
^c Université de Nantes, UFR Médecine, 44042 Nantes, France
^d CHU Nantes, Département de Rhumatologie, PHU 4 OTONN, 1, place Alexis Ricordeau, 44042 Nantes, France
^e Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

^*Corresponding author at: CHU Nantes, Département de Rhumatologie, PHU 4 OTONN, 1, place Alexis Ricordeau, 44042 Nantes, France.CHU Nantes, Département de Rhumatologie, PHU 4 OTONN1, place Alexis RicordeauNantes44042France

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Abstract

Osteoarthritis affects hundreds of millions of people worldwide, and its prevalence is constantly increasing. While there is currently no treatment that can alter the course of the disease, promising therapeutic strategies and novel targets are being investigated. Innovative cell therapies are already reaching clinical trials, and recent progress in our understanding of the disease is opening new routes for gene therapy. In the long term, the development of new biofabrication tools, such as 3D bioprinting, may pave the way for personalized mini-joint models that could be used to screen drugs and to personalize treatments. This review provides an overview of the most promising therapeutic approaches in the field of osteoarthritis, from upcoming treatments to those that are yet to be discovered.

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Keywords : Osteoarthritis, Cell therapy, Encapsulation, Therapeutic target, Gene therapy, Bioprinting, 3D models