Role of miRNA and lncRNAs in organ fibrosis and aging - 09/10/21
, Mohammad Taheri f, ⁎ , Nader Akbari Dilmaghani g, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Fibrosis is the endpoint of pathological remodeling. This process contributes to the pathogenesis of several chronic disorders and aging-associated organ damage. Different molecular cascades contribute to this process. TGF-β, WNT, and YAP/TAZ signaling pathways have prominent roles in this process. A number of long non-coding RNAs and microRNAs have been found to regulate organ fibrosis through modulation of the activity of related signaling pathways. miR-144-3p, miR-451, miR-200b, and miR-328 are among microRNAs that participate in the pathology of cardiac fibrosis. Meanwhile, miR-34a, miR-17-5p, miR-122, miR-146a, and miR-350 contribute to liver fibrosis in different situations. PVT1, MALAT1, GAS5, NRON, PFL, MIAT, HULC, ANRIL, and H19 are among long non-coding RNAs that participate in organ fibrosis. We review the impact of long non-coding RNAs and microRNAs in organ fibrosis and aging-related pathologies.
Le texte complet de cet article est disponible en PDF.Abbreviation : HCFs, Col1α1, α-SMA, PTEN, MHECs, AMPK, CFs, DNMT3A, P62, CMs, CD, hiPSC, TGF-β1, NLRC5, CKD, PI3K, IGF-1, CTGF, FN1, AS-IV, SMAD, HCMECs, IRAK1, AngII, circRNAs, MMP16, p38 MAPK, GSK-3β, FBXW4, FBXW7, MiRNAs, Ago2, TGFβR2, BMP-7, IL-6, Sirt1, NF-κB, ASICs, MAPK/ERK, SPRY2, METTL3, HK-2, Zeb2, FGF11, FOXO, NLRP3, ASC, PGC-1a, PPARα, PVT1, NRON, GAS5, MMP-2, PFL, CF, lnc RNF7, PCFL, GRB2, MIAT, NLRP3, ACC, MALAT1, FAK
Keywords : LncRNA, MiRNA, Aging, Organ fibrosis
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Vol 143
Article 112132- novembre 2021 Retour au numéro
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