Imaging markers of intracranial aneurysm development: A systematic review - 15/10/21
, Birgitta K. Velthuis b, Ynte M. Ruigrok aCet article a été publié dans un numéro de la revue, cliquez ici pour y accéder
Highlights |
• | We systematically reviewed imaging markers of intracranial aneurysm development. |
• | Many studies had poor methodological quality and varied in marker definitions and outcomes used. |
• | We only found one anatomical imaging marker with converging evidence, A1 segment asymmetry. |
• | A meta-analysis was however not possible due to the use of different definitions of A1 asymmetry across studies. |
• | Future studies should employ robust study designs to clarify the role of the identified markers. |
Abstract |
Background |
Imaging markers of intracranial aneurysm (IA) development are not well established.
Purpose |
To provide an overview of imaging markers of IA development.
Methods |
A systematic search of PubMed and Embase up to December 1st 2020 using predefined criteria. Thirty-six studies met our inclusion criteria. We performed a quantitative summary of the included studies.
Results |
We found converging evidence for A1 segment asymmetry as an anatomical marker of anterior communicating artery (Acom) aneurysm development, and moderate evidence for several other markers. No hemodynamic markers yielded converging or moderate evidence. There was large heterogeneity across studies, especially in the definitions of imaging markers and study outcomes used. Due to the poor methodological quality of many studies and unavailability of effect sizes or crude data to calculate effect sizes, a formal meta-analysis was not possible. Many studies had poor methodological quality and varied inmarkerdefinitions and outcome measuresused, which prevented us from performing a formal meta-analysis.
Conclusions |
We only identified A1 segment asymmetry as an imaging marker of Acom aneurysm development with converging evidence. A meta-analysis was not possible due to the heterogeneity of marker definitions and outcomes used, and poor methodological quality of many studies. Future studies should use robust study designs and uniformly defined imaging markers and outcome measures.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Keywords : Imaging marker, Intracranial aneurysm, Neuroimaging, Subarachnoid hemorrhage
Abbreviations : ACA, BA, IA, ICA, MCA, PCA, Pcom, VA, WSS
Plan
| Disclosure of Funding We acknowledge the support from the Netherlands Cardiovascular Research Initiative: An initiative with support of the Dutch Heart Foundation, CVON2015-08 ERASE. This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No. 852173). |
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| Conflict of Interest None. |
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