Quality of evidence of the efficacy of therapeutic interventions on patient-important outcomes in Cochrane's systematic reviews’ abstracts: A survey - 15/10/21
, Benoît Tudrej c, Elodie Tawil c, Florian Naudet d, e, Caroline Huas f, g, Denis Pouchain h, Hélène Vaillant-Roussel i, Nemat Jaafari j, Rémy Boussageon a, bBienvenue sur EM-consulte, la référence des professionnels de santé.
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Summary |
Objective |
The objective of this study was to evaluate the proportion of therapeutics that have proven their efficacy on patient-important outcomes with a high quality of evidence among Cochrane systematic reviews (SRs).
Methods |
We surveyed a random sample of 400 SRs’ abstracts published between September 2012 and December 2015, which compared therapeutic interventions with at least a placebo or no intervention control. The primary endpoint was the proportion of SRs with a statistically significant efficacy on a patient-important outcome and with a high quality of evidence.
Results |
Among the 400 abstracts surveyed, 32 (8%) found efficacy on a patient-important outcome with a high quality of evidence. Half of the 400 SRs (50.2%) evaluated a pharmacological intervention and 12% of these found efficacy of the intervention on a patient-important outcome with a reported high quality of evidence.
Conclusion |
Based on an analysis of 400 abstracts of SRs from the Cochrane Collaboration, we found that there is a low number of therapeutic interventions which have proven their efficacy on patient-important outcomes with a high quality of evidence.
Le texte complet de cet article est disponible en PDF.Keywords : Systematic review, Evidence-based medicine, GRADE approach, Patient-important outcome
Plan
Vol 76 - N° 5
P. 403-408 - septembre 2021 Retour au numéro
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