Effect of patient-controlled epidural analgesia with and without automatic intermittent bolus on levobupivacaine consumption during labour: A single-centre prospective double-blinded randomised controlled study - 20/10/21
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Abstract |
Background |
During labour, the effects of adding a programmed intermittent epidural bolus (PIEB) baseline analgesic regimen to patient-controlled epidural analgesia (PCEA) remain uncertain.
Methods |
This single centre prospective double-blinded controlled study randomised nulliparous women over 35 weeks of gestational age in a PCEA + PIEB or PCEA only group. After an epidural analgesia catheter was inserted, a specific pump administered a solution of levobupivacaine 0.625 mg mL−1, sufentanil 0.25 µg mL−1, and clonidine 0.375 µg mL−1. In both groups the PCEA mode delivered an 8 mL bolus with a lockout period of 8 min. In the PCEA + PIEB group, women also received a programmed 8 mL bolus every 60 min. Additional bolus were allowed if required. The primary outcome was the hourly consumption of levobupivacaine from epidural catheter placement to new-born delivery. Secondary outcome were motor block, oxytocin use, sufentanil consumption, additional bolus required, instrumental vaginal delivery, unplanned caesarean section, pain during labour and women’s satisfaction.
Results |
Analysis included 162 and 155 women in the PCEA and PCEA + PIEB groups, respectively. The median [IQR] hourly consumption of levobupivacaine was significantly lower in the PCEA group (9.9 (7.8–12.4] mg h−1) as compared to the PCEA + PIEB group (11.2 [7.9–14.3] mg h−1; p = 0.046). The difference between medians was 1.3 mg h−1 95 % CI (0.1–2.9). There was no difference between groups for secondary outcomes.
Conclusions |
PCEA only modestly decreased the hourly consumption of local anaesthetic as compared to PCEA + PIEB but the difference was not clinically relevant.
Le texte complet de cet article est disponible en PDF.Keywords : Labour analgesia, Epidural analgesia, Patient-Controlled, Levobupivacaine
Plan
Vol 40 - N° 5
Article 100936- octobre 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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