Post-partum relapse in women with multiple sclerosis after neuraxial labour analgesia or neuraxial anaesthesia: A multicentre retrospective cohort study - 20/10/21
, Margaux Fontana a, Anne-Sophie Bouthors c, Martine Bonnin d, Brigitte Storme d, Françoise Bayoumeu e, Gérard Corsia f, Sandra Vukusic g, h, i, Dominique Chassard a, bBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Background |
The proportion of women with multiple sclerosis experiencing a relapse in the post-partum period after neuraxial labour analgesia or neuraxial anaesthesia remains uncertain. This study aimed to assess the association between neuraxial labour analgesia or neuraxial anaesthesia and the occurrence of relapse during the first three months post-partum.
Methods |
In this retrospective cohort study, cases of women with a diagnosis of multiple sclerosis delivering between January 2010 and April 2015 were analysed. Demographic, anaesthetic and obstetric characteristics, occurrence and number of relapses in the year preceding pregnancy, during pregnancy, and the first three post-partum months, were recorded. Logistic regression analyses were performed for the identification of factors associated with the occurrence of post-partum relapse.
Results |
A total of 118 deliveries in 104 parturients were included, these were 78 (66%) vaginal deliveries and 40 (34%) caesarean deliveries. Neuraxial analgesia was provided in 50 deliveries, and neuraxial anaesthesia in 46 deliveries; no neuraxial anaesthesia or analgesia was administered in remaining 22 deliveries. Post-partum relapse occurred in 31 women (26%). There was no association between obstetric or anaesthetic characteristics and post-partum relapse. Both the occurrence and number of relapses prior to and during pregnancy, and the time between last relapse and delivery, were significantly associated with post-partum relapse in univariate analysis. The occurrence of relapse within the year preceding the pregnancy was the sole independent factor associated with post-partum relapse.
Conclusion |
Neuraxial procedures were not associated with increased rate of post-partum relapse; only disease activity prior to pregnancy was predictive of post-partum relapse.
Le texte complet de cet article est disponible en PDF.Keywords : Multiple sclerosis, Pregnancy, Post-partum, Relapses, Neuraxial anaesthesia, Neuraxial analgesia
Plan
| ✰ | Presentation: Presented in part at the French Society of Anaesthesia and Intensive Care annual congress (Congrès de la Société française d’anesthésie et de réanimation), September 2017, Paris, France. |
Vol 40 - N° 5
Article 100834- octobre 2021 Retour au numéro
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