Hepatotoxicity of iodine-131 ablation for post-surgical differentiated thyroid cancer patients with hepatitis B virus infection - 11/11/21
, Zenan Huang c, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | Incidence of hepatotoxicity is higher in HBV group receiving radioiodine ablation treatment than non-HBV group. |
• | HBV infection is a significant risk factor of hepatotoxicity for patients treated by radioiodine ablation. |
• | Liver function and HBV DNA levels should be monitored in HBV infected patients when treated by radioiodine ablation. |
Abstract |
Objective |
Radioiodine (Iodine-131, 131I) ablation is a standard treatment for differentiated thyroid cancer (DTC) after thyroidectomy. Hepatotoxicity is a rare side effect of 131I, and little information is available on the hepatotoxicity of 131I ablation for post-surgical DTC patients with hepatitis B virus (HBV) infection.
Methods |
We performed a retrospective study of 94 post-surgical DTC patients between November 2012 and August 2015 in our hospital. All the patients had been screened for HBV infection and divided into HBV group and non-HBV group. Clinical data were compared between the two groups.
Results |
14 patients with HBV infection and 80 patients without HBV infection were analyzed. The baseline characteristics of the two groups had no statistical differences. Incidence of hepatotoxicity was higher in HBV group than in non-HBV group and HBV infection was confirmed as a risk factor of hepatotoxicity by univariate and multivariate regression analysis.
Conclusion |
Post-surgical DTC patients with HBV infection were prone to hepatotoxicity by 131I ablation treatment. Physicians should pay more attention to the liver function of patients at risk.
Le texte complet de cet article est disponible en PDF.Keywords : Thyroid cancer, Radioiodine, Hepatitis B virus, Hepatotoxicity
Plan
Vol 45 - N° 6
Article 101631- novembre 2021 Retour au numéro
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