Genetic polymorphism of fibroblast growth factor receptor 2 and trinucleotide repeat-containing 9 influence the susceptibility to HCV-induced hepatocellular carcinoma - 11/11/21
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| pages | 11 |
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Highlights |
• | Preventive measures of hepatocellular carcinoma (HCC) by recognizing its risk factors are crucial. |
• | Genetic variations in genes that regulate pivotal cellular processes are potential candidates for HCC risk factors. |
• | Single nucleotide polymorphisms (SNPs) in FGFR2 and TRNC9 have been associated with some malignancies. |
• | SNPs in FGFR2 and TNRC9 gene were associated with HCC risk, suggesting their implication in hepatocarcinogenesis in HCV- infected patients. |
Abstract |
Background |
Fibroblast growth factor receptor 2 (FGFR2) and trinucleotide repeat-containing 9 (TNRC9) gene polymorphisms have been associated with some cancers. We aimed to assess the association of FGFR2 rs2981582 and TNRC9 rs12443621 polymorphisms with hepatocellular cancer risk.
Methods |
One hundred patients with HCV-induced HCC, 100 patients with chronic HCV infection, and 100 controls were genotyped for FGFR2 rs2981582 and TNRC9 rs12443621 using allele-specific Real-Time PCR analysis.
Results |
FGFR2 rs2981582 genotype TT was associated with increased risk of HCC when compared to controls (OR = 3.09, 95% CI = 1.24–7.68). However, it was significantly associated with a lower risk of HCC when using HCV patients as controls (OR = 0.21, 95% CI = 0.09–0.5), and T-allele of FGFR2 appears to be a protective allele against HCC in HCV patients (OR = 0.42, 95% CI = 0.21−0.85). While AG and GG genotypes of TNRC9 rs12443621 were linked with significantly increased risk of HCC (OR = 3.91, 95% CI = 2.02–7.6 and OR = 9.26, 95% CI = 3.21–26.7 respectively) and HCV patients carrying G allele were at increased risk of HCC by 2.7-fold. A significant high frequency of small tumor size and early-stage of HCC were observed in patients carrying FGFR2 rs2981582 genotype CT and TT (P = 0.029 and <0.001 respectively), while, TNRC9 rs12443621 genotype AG and GG were associated large tumor size and late-stage of HCC (P < 0.001 and 0.015 respectively).
Conclusions |
SNPs in rs2981582 for FGFR2 and rs12443621 for TNRC9 gene were associated with HCC susceptibility, suggesting their implication in hepatocarcinogenesis in chronically HCV-infected patients.
Le texte complet de cet article est disponible en PDF.Keywords : Hepatocellular carcinoma, Polymorphism, FGFR2, TNRC9, Susceptibility
Plan
Vol 45 - N° 6
Article 101636- novembre 2021 Retour au numéro
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