Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties - 13/11/21
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Abstract |
The resin/gum of Boswellia species belonging to the family of Burseraceae is a naturally occurring mixture of bioactive compounds, which was traditionally used as a folk medicine to treat conditions like chronic inflammation. Several research studies have also explored its’ therapeutic potential against multiple neurodegenerative diseases such as Alzheimer’s disease (AD). The main chemical constituents of this gum include boswellic acids (BAs) like 3-O-acetyl-11-keto-β boswellic acid (AKBA) that possess potent anti-inflammatory and neuroprotective properties in AD. It is also involved in inhibiting the acetylcholinesterase (AChE) activity in the cholinergic pathway and improve choline levels as well as its binding with nicotinic receptors to produce anti-inflammatory effects. Multiple shreds of evidence have demonstrated that BAs modulate key molecular targets and signalling pathways like 5-lipoxygenase/cyclooxygenase, Nrf2, NF-kB, cholinergic, amyloid-beta (Aβ), and neurofibrillary tangles formation (NFTs) that are involved in AD progression. The present review focuses on the possible mechanistic therapeutic role of BAs in modulating the 5-LOX/COX pathway in arachidonic acid metabolism, activating Nrf2 through binding of ARE, inhibiting NF-kB and AChE activity. In addition, an inhibition of amyloid plaques (Aβ) and neurofibrillary tangles (NFTs) induced neurotoxicity and neuroinflammation in AD by BAs is also discussed in this review. We have also highlighted that BAs possess beneficial effects in AD by targeting multiple molecular pathways and makes it an emerging drug candidate for treating neurodegenerative diseases.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | BAs: A pleiotropic agent and its mechanistic role in multiple cascades. |
• | Signaling pathways influenced by BAs are Nrf2, NF-kB, and AChE. |
• | Targets molecules like 5-LOX/COX, amyloid plaques, and neurofibrillary tangles. |
• | Promising anti-inflammatory drug candidate for treating neurodegenerative diseases. |
Keywords : Boswellic acids, Neuroinflammation, Inflammatory mediators, Alzheimer’s disease, Signalling pathways
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Vol 144
Article 112250- décembre 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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