Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice - 13/11/21
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Abstract |
Jasminum grandiflorum L. is a medicinal plant used to treat hepatitis and gastritis, but the mechanisms underlying its protective effects against gastrointestinal mucosal damage remain to be elucidated. In this study, we analyzed the effects of four different extracts and two compounds from the flower of J. grandiflorum in a mouse model of HCl/EtOH-induced gastric ulcer. The flower extracts alleviated gastric mucosal ulceration by increasing PGE2 production and the activity of antioxidant enzymes, along with the suppression of reactive oxygen species (ROS) generation, lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines and nitric oxide (NO) production.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | PET extract of J. grandiflorum flowers and compound HT exert gastroprotective effects. |
• | PET alleviates gastric mucosal ulcer in mice by regulating the NF-κB pathway. |
• | HT alleviates gastric mucosal injury in mice mainly by reducing oxidative stress. |
• | PET has a potent anti-inflammatory effect in LPS-stimulated RAW264.7 macrophages. |
Keywords : Inflammation, Oxidative stress, Gastrointestinal mucosal damage, Apoptosis
Plan
Vol 144
Article 112268- décembre 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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